Relax by Port St. Lucie Hotels Grotto Waterfall. Welcome to Floridas Treasure Coast renowned for its sunken Spanish ships gorgeous unpopulated beaches and fascinating biological diversity. The Holiday Inn Port St. Lucie hotel is in the heart of the Treasure Coast surrounded by picturesque towns parks and waterways. Stay with us and enjoy all the comforts of home as this hotels valued guest. In Port St. Lucie Florida you can play a round of golf at PGA Village and watch the NY Mets train at Digital Domain Park. Patrons can also visit Fort Pierce our neighboring town to tour the A.E. Backus Museum catch a show at the historic Sunrise Theater and observe manatees at Moores Creek. Many nearby companies lead daily kayaking dolphin watching and fishing excursions as well. We offer business friendly amenities and a convenient location on US 1 too. Stay in touch with the office with free wireless Internet access and a 24 hour Business Center in the hotel. St. Lucie Medical Center and Liberty Medical are just minutes from the hotels location in Port St. Lucie Florida. Pamper yourself with a dip in the heated free form pool with a grotto waterfall a soak in the hot tub and a cocktail at Gatwicks Lounge. Start planning your Treasure Coast vacation now by booking a room at this green certified hotel where you help protect the areas endangered ecosystems every time you stay as our partner in the Clean the World program.